Publications
Dr. Sivaramakrishnan

Molecular Jigsaws @ Quest Compbio
Pipelines that just fit

List of Publications 

Karel Wiesner, Thomas Y. R. Tsai, Ravindra Kumar, Hariharan Sivaramakrishnan; Communication XV. A stereoselective synthesis of (21R)-21-methyldigitoxigenin, a fully active cardenolide with a wide margin of safety: A contribution to the topology of the Digitalis receptors; Helvetica Chimica Acta June 1984; 67(4): 1128-1135.

Smith AB; Liverton NJ; and Sivramakrishnan H; Total synthesis of (+) – Jatropholone_A and (+)-Jatropholone-B; Journal of Organic Chemistry 1985 50(17): 3239-3241.

Smith AB; Liverton NJ; and Sivaramakrishnan; Total synthesis of SIS OF (+)-Jatropholone _A and (+)- Jatropholone-B exploitation of the high-pressure technique. H JACS 1986 108(11): 3040-3048.

D. Gravel, S. Benoît, S. Kumanovic and H. Sivaramakrishnan; On the palladium catalyzed reaction of methallyl-l, l-diacetate with cyclic β-ketoesters. Intervention of hidden mechanisms; Tetrahedron Letters Mar 1992 33(11): 1403 – 1406.

D.Gravel,, S.Benoît, S.Kumanovic and H.Sivaramakrishnan; Novel palladium catalyzed bicycloannulation of monoactivated cyclic ketones using a 1,3-allylic diacetate and an enolzying catalyst. Tetrahedron Letters Mar 1992 33(11): 1407-1410.

H. Sivaramakrishnan et. al.; Synthesis of ciprofloxacin; Indian Journal of Chemistry 1997 36 B: 347 – 348.

H. Sivaramakrishnan et. al.; Stereochemistry of Gabapentin and several derivatives solid state confirmations and solutions equilibria; Current Science, 2003, 85 (7).

H. Sivaramakrishnan et. al.; Synthesis of triphenyl 1, 2, 3 triazoles – communicated; Indian Journal of Chemistry.

Sameer Dhuru, Dilip Bhedi, Dnyaneshwar Gophane, Kiran Hirbhagat, Vijaya Nadar, Dattatray More, Sapna Parikh, Roda Dalal, Lyle C. Fonseca, Firuza Kharas, Prashant Y. Vadnal, Ram A. Vishwakarma, H. Sivaramakrishnan; Novel Diarylheptanoids As Inhibitors Of TNF-A Production; Bioorg. Med. Chem. Lett. 21 (2011) 3784–3787.

A. John Blacker, Mita Roy, Sivaramkrishnan Hariharan, Catherine Headley, Abhay Upare, Ashutosh Jagtap, Karuna Wankhede, Sushil Kumar Mishra, Dagadu Dube, Sanjay Bhise, Sandesh Vishwasrao, and Nitin Kadam; Convenient Method for Synthesis of N-Protected r-Amino Epoxides: Key Intermediates for HIV Protease Inhibitors; Organic process research & development, 2011, vol. 15, page no. 331-338.

Pradipta Tokdar, Prafull Ranadive, Saji George, Abhay Upare, Sandesh Vishwasrao, Mita Roy, and H. Sivaramakrishnan; Bakers’ Yeast Mediated Stereo Selective Reduction of Cis (+) Diketolactam to Cis (+) Hydroxylactam, a Key Intermediate for Diltiazem Synthesis in a Laboratory Scale Bioreactor; International Journal of Chemical Engineering and Applications, Vol. 2, No. 6, December 2011.

Chandrika B-Rao, Asha Kulkarni-Almeida, Kamlesh V. Katkar, Smriti Khanna, Usha Ghosh , Ashish Keche, Pranay Shah , Ankita Srivastava, Vaidehi Korde, Kumar V.S. Nemmani, Nitin J. Deshmukh, Amol Dixit, Manoja K. Brahma, Umakant Bahirat, Lalit Doshi, Rajiv Sharma, H. Sivaramakrishnan; Identification Of Novel Isocytosine Derivatives As Xanthine Oxidase Inhibitors From A Set Of Virtual Screening Hits; Bioorg. Med. Chem. 20 (2012) 2930–2939.

Smriti Khanna, Sandeep Burudkar, Komal Bajaj, Pranay Shah, Ashish Keche, Usha Ghosh, Avani Desai, Ankita Srivastava, Asha Kulkarni-Almeida, Nitin J. Deshmukh, Amol Dixit, Manoja K. Brahma, Umakant Bahirat, Lalit Doshi, Kumar V. S. Nemmani, Prashant Tannu, Anagha Damre, Chandrika B-Rao, Rajiv Sharma, H. Sivaramakrishnan; Isocytosine-Based Inhibitors Of Xanthine Oxidase: Design, Synthesis, SAR, PK and In Vivo Efficacy In Rat Model Of Hyperuricemia; Bioorg. Med. Chem. Lett. 22 (2012) 7543–7546.

Ravindra D. Jadhav, Kishorkumar S. Kadam, Shivaji Kandre, Tandra Guha, M. Mahesh Kumar Reddy, Manoja K. Brahma, Nitin J. Deshmukh, Amol Dixit, Lalit Doshi, Nisha Potdar, Arno A. Enose, Ram A. Vishwakarma, H. Sivaramakrishnan, Shaila Srinivasan, Kumar V.S. Nemmani, Amol Gupte, Ashok K. Gangopadhyay, Rajiv Sharma; Synthesis and biological evaluation of isoxazole, oxazole, and oxadiazole containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors; European Journal of Medicinal Chemistry 54 (2012) 324-342.

Swapnil Bajare, Jessy Anthony, Amrutha Nair, Rosalind Marita, Anagha Damre, Dharmeshkumar Patel, Chandrika Rao, H. Sivaramakrishnan, Nabajyoti Deka; Synthesis of N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl)benzenesulfonamide derivatives as non-TZD peroxisome proliferator-activated receptor γ (PPAR γ) agonist; European Journal of Medicinal Chemistry 58 (2012) 355-360.

Komal Bajaj, Sandeep Burudkar, Pranay Shah, Ashish Keche, Usha Ghosh, Prashant Tannu, Smriti Khanna, Ankita Srivastava, Nitin J. Deshmukh, Amol Dixit, Yogesh Ahire, Anagha Damre, Kumar V. S. Nemmani, Asha Kulkarni-Almeida, Chandrika B-Rao, Rajiv Sharma, H. Sivaramakrishnan; Lead Optimization Of Isocytosine-Derived Xanthine Oxidase Inhibitors; Bioorg. Med. Chem. Lett. 23 (2013) 834–838.

Girish Mahajan, Becky Thomas, Rajashri Parab, Zarine E. Patel, Sandip Kuldharan, Vijayaphanikumar Yemparala, Prabhu Dutt Mishra, Prafull Ranadive, Lisette D’Souza Koteppa Pari and H. Sivaramkrishnan; In Vitro and In Vivo Activities of Antibiotic PM181104; Antimicrobial Agents and Chemotherapy, 57 (11), 2013, p. 5315-5319.

Koteppa Pari, Girish Mahajan, Rajendra Kshirsagar, Vijayaphanikumar Yemparala, Rajashri Parab, Prashant Shanbhag, Becky Thomas, Arati Prabhu, Chandrika Rao, Venkat Manohar, H. Sivaramakrishnan; In Vitro Anti-Clostridium difficile Activity, Mode of Action and Structural Modeling Studies of PM2409, A Semisynthetic Cycle Thiopeptide Antibiotic; The Journal of Antibiotics, 2 July 2014, doi:10.1038/ja.2014.88

Nabajyoti Deka, Mahesh Uravane , Jessy Anthony, Sujit Kaur Bhumra , Amrutha Nair, Chandrika B-Rao , Dharmeshkumar Patel , H. Sivaramakrishnan; Design and synthesis of non-TZD peroxisome proliferator activated receptor g (PPARg) modulator; Med Chem Res (2014) 23:2150–2159.

Nabajyoti Deka, Swapnil Bajare, Jessy Anthony, Amrutha Nair, Anagha Damre, Dharmeshkumar Patel, Chandrika B-Rao, H. Sivaramakrishnan, Shivaprakash Jagalur Mutt, ChandanWilankar, and Rosalind Marita; “Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome,” International Journal of Medicinal Chemistry, vol. 2013, Article ID 201580, 10 pages, 2013.

Anthony J, Kelkar A, Wilankar C, Ranjith V, Bhumra SK, Shivaprakash Mutt, Nabajyoti Deka, Hariharan Sivaramakrishnan, Somesh Sharma, Adaikalasamy Rosalind Marita; (2013) Discovery of P1736, a Novel Antidiabetic Compound That Improves Peripheral Insulin Sensitivity in Mice Models. PLoS ONE 8(10): e77946.

Arno A Enose, Priya K Dhasan, H. Sivaramakrishnan, Sanket M Shah; Formulation and Characterization of Solid Dispersion Prepared by Hot Melt Mixing: A Fast Approach for Polymer Selection; Journal of Pharmaceutics; Date of publication: 12 March 2014, Volume 2014, Article ID 105382, 13 pages

Geetanjali Chimote, Jayasree Sreenivasan and H Sivaramakrishnan; Zebrafish for pharmaco-toxicological evaluation of anti-angiogenic agents in drug discovery: Drug Design,Development and Therapy 2014:1-17

Geetanjali Chimote, Jayasree Sreenivasan, Shruta Dadarkar, Noopur Mandrekar, Madhura Narkar, Nishigandha Naik , Urvashi Panghal, H. Sivaramakrishnan, Somesh Sharma; Predicting drug induced valvulopathy: the zebrafish paradigm; Communication Biochemical Pharmacology.

Hariharan Sivaramakrishnan, Abhay A. Upare, Damodharan Satagopan, and Owen R. Chambers; The Preparation of Desflurane by the Vapor-Phase Fluorination of Isoflurane; Organic Process Research and Development; dx.doi.org/10.1021/op100318b

Shirsath N, Rathos MJ, Chaudhari U, Sivaramakrishnan H, Joshi K; Potentiation of anticancer effect of Valproic acid, an antiepileptic agent with histone deacetylase inhibitory activity, by the cyclin-dependent kinase inhibitor P276-00 in non-small cell lung cancer cell lines; Lung Cancer 2013; 82: 214-21

Patent publications/patent applications filed in the name of Piramal Enterprises Limited wherein Dr. H. Sivaramakrishnan has been named as an inventor

I. Patent applications pertaining to NCE Research:

DEKA, Nabajyoti; HARIHARAN, Sivaramakrishnan; BAJARE, Swapnil, Ramesh; MARITA, Rosalind, Adaikalasamy, “Pyridine Derivatives For The Treatment Of Metabolic Disorders Related To Insulin Resistance Or Hyperglycemia”, PCT Publication No.: WO2008/035305, Published on March 27, 2008

DEKA, Nabajyoti; PADIYA, Kamlesh, Jyotindra; BAJARE, Swapnil, Ramesh; KULKARNI, Rhushikesh, Arun; KHAN, Taj, Usman; HARIHARAN, Sivaramakrishnan; MARITA, Rosalind, Adaikalasamy, “3-Amino-Pyridine Derivatives For The Treatment Of Metabolic Disorders”, PCT Publication No.: WO2008/035306, Published on March 27, 2008

KUMAR, Sanjay; HARIHARAN, Sivaramakrishnan; BHONDE, Mandar; DAGIA, Nilesh; SHARMA, Rajiv; MANE, Pallavi Hanmantrao; KUMAR, Pramod Bhaskar, “Imidazopyridine Derivatives”, PCT Publication No.: WO2011/055320, Published on May 12, 2011

CHIMOTE Geetanjali Chandrashekhar, MAHAJAN Girish Badrinath, VASUDEVAN Aravindan, HARIHARAN Sivaramakrishnan; “Microparticle formulation for pulmonary drug delivery of anti-infective molecule for treatment of infectious diseases”, PCT Publication No.: WO 2012/017405, Published on February 09, 2012

CHENNAMSETTY, Suneel Manohar Babu; JOSHI, Kishor; CHINCHWADE, Yogesh; HULAWALE, Yogesh; PARAMASIVAN, Selvam; SIVAKUMAR, Meenakshi; HARIHARAN, Sivaramakrishnan; “A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation”, PCT Publication No.: WO 2012/143879, Published on October 26, 2012

CHENNAMSETTY, Suneelmanoharbabu; BOKKA, Ravishankar; VEERAPPAN, Rathinasami; SIVAKUMAR, Meenakshi; HARIHARAN, Sivaramakrishnan; “A process for preparation of an intermediate of the pyrrolidine substituted flavones“, PCT Application No.: PCT/IB2013/051331, Filed on February 19, 2013

CHENNAMSETTY, Suneelmanoharbabu; PATIL, Rajendra; HAREL, Prashant; HARIHARAN, Sivaramakrishnan; “An improved process for preparation of an intermediate of the pyrrolidine substituted flavones”, PCT Application No.: PCT/IB2013/051334, Filed on February 19, 2013

SIVAKUMAR, Meenakshi; JOSHI, Kalpana Sanjay; HARIHARAN, Sivaramakrishnan; BOKKA, Ravi Sankar; AWARE, Valmik Sopan; MANOHAR, Sonal; SONAWANE, Vinay; CHENNAMSETTY, Suneel Manohar Babu; THOMAS, Becky Mary; TRIVEDI, Jacqueline Vinodkumar, “Substituted pyrimidine compounds and uses thereof “, PCT Publication No.: WO2013175415A1, Published on November 28, 2013

DEKA Nabajyoti; SHARMA Rajiv; HARIHARAN Sivaramakrishnan; URAVANE Mahesh; CHAVAN Kamlesh; MEDHI Santanu, “Pyridyl compound suitable for the treatment of metabolic disorders”, PCT Application No.: PCT/IB2013/055278, Filed on June 27, 2013

CHIMOTE Geetanjali, SHARMA Somesh, SREENIVASAN Jayasree, HARIHARAN Sivaramakrishnan; “Pyrrolidine substituted flavones for treatment of renal cystic diseases”, PCT Publication No.: WO/2014049515, Published on April 03, 2014

HARIHARAN, Sivaramakrishnan; KATE Abhijeet Sudhir; THOMAS Becky Mary; KULKARNI-ALMEIDA Asha; TRIVEDI Jacqueline Vinodkumar; JADHAV Mahesh Gundaji; SHAH Meet, “Macrocyclic lactone derivatives and uses thereof”, PCT Application No.: PCT/IB2014/058693, Filed on January 31, 2014

CHENNAMSETTY Suneelmanoharbabu; BOKKA Ravishankar; PARAMASIVAN Selvam; HARIHARAN Sivaramakrishnan; HULAWALE Yogesh, “An improved process for the preparation of a biphenyl-4-yl- methyl- pyrrolidin-2-one derivative”, Indian Patent Application: 2719/MUM/2013, Filed on August 20, 2013

HARIHARAN Sivaramakrishnan; CHENNAMSETTY Suneelmanoharbabu; BOKKA Ravishankar; HULAWALE Yogesh; PATIL Arun; KALE Ganesh; PARAMASIVAN Selvam, “Pyrimidinamine compounds and uses thereof”, US Provisional Patent Application: 61/885,076, Filed on October 01, 2013

CHENNAMSETTY Suneelmanoharbabu; HULAWALE Yogesh; PARAMASIVAN Selvam; HARIHARAN Sivaramakrishnan; “Process for the preparation of substituted imidazo[4,5-C]quinoline compounds, intermediates and polymorphs thereof”, Indian Provisional Patent Application: 1077/MUM/2014, Filed on March 27, 2014

CHENNAMSETTY Suneelmanoharbabu; BOKKA Ravishankar; HARIHARAN Sivaramakrishnan; HULAWALE Yogesh; 2013, “An Improved Process for the Preparation of a Biphenyl-4-Yl- Methyl-pyrrolidin-2-one Derivative,” Indian patent application no. 2719/MUM/2013.

HARIHARAN Sivaramakrishnan; CHENNAMSETTY Suneelmanoharbabu; BOKKA Ravishankar; and Co-workers, 2013, “Pyrimidinamine Compounds and Uses Thereof,” US application no.61/885, 076 on 01 Oct 2013.

II. Patent applications pertaining to Process Research:

UPARE, Abhay, PAWAR, Nitin Yeshwant, WAGH, Ganesh, CHAVAN, Amit, ROY, Mita, HARIHARAN Sivaramakrishnan; “Novel intermediates useful for the preparation of coenzymes, process for the preparation of the said novel intermediates and an improved process for the preparation of coenzymes“, PCT Publication no.: WO 2007/004091, Published on January 11, 2007

GURUMURTHY Palanivelu, CHENNAMSETTYL Suneel Manohar Babu, VISWESWARAN Vaithyanathan, Roy Mita, HARIHARAN Sivaramakrishnan; “Novel intermediates, process for their preparation and process for the preparation of CoQ10 employing the said novel intermediates”, PCT Publication no.: WO 2007/004092, Published on January 11, 2007

ROY Mita, UPARE Abhay Atmaram, HARIHARAN Sivaramakrishnan;WAGH Ganesh Baburao, “Improved process for the synthesis of COQ10”, PCT Publication no.: WO2007/129268, Published on November 15, 2007

HARIHARAN Sivaramakrishnan; CHAMBERS, Owen, UPARE, Abhay Atmaram, SATAGOPAN, Damodharan, “Process for production of 1,2,2,2 – tetra fluoro ethyl difluoro methyl ether”, PCT Publication no.: WO2009/010908, Published on January 22, 2009

HARIHARAN Sivaramakrishnan; ROY Mita, UPARE Abhay, MISHRA Sushil Kumar,
CRASTA Santosh, WANKHEDE Karuna, VISHWASRAO Sandesh, “Process For Stereoselective Preparation Of An Intermediate Of Protease Inhibitors”, PCT Publication no.: WO2010/143150, Published on December 16, 2010

UPARE, Abhay Atmaram; MISHRA, Sushil Kumar; CRASTA, Santosh; WANKHEDE, Karuna; VISHWASRAO, Sandesh; HARIHARAN Sivaramakrishnan; ROY, Mita, “Process For Enantioselective Preparation Of Nitroketone, An Intermediate Of Protease Inhibitors”, PCT Publication No.: WO/2011/061675, Published on May 26, 2011

JAGTAP Ashutosh, ROY Mita, HARIHARAN Sivaramakrishnan; PAWAR Nitin, VISWASRAO Sandesh, BHISE Sanjay, “An improved process for the preparation of valacyclovir hydrochloride”, Indian Publication No. 3353/MUM/2010A, Published on June 28, 2013

ROY, Mita; JAGTAP, Ashutosh; SHAH, Chirag; KUMBHAR, Ajay; HARIHARAN Sivaramakrishnan; “A process for the isolation of emtricitabine”, PCT Publication No.: WO2012/131541, Published on October 04, 2012

WANKHEDE, Karuna; JAGTAP, Ashutosh, ROY, Mita; HARIHARAN Sivaramakrishnan; KUMBHAR, Ajay, “A process for preparation of intermediate of moxifloxacin”, PCT Publication No.: WO2012/131629, Published on October 04, 2012

HARD Ajay, JAGTAP Ashutosh, ROY Mita, HARIHARAN Sivaramakrishnan; “An improved process for racemization of (s)-3-(carbamoylmethyl)-5-methylhexanoic acid”, PCT Publication No.: WO2014/016776, Published on January 30, 2014

WAGH, Ganesh; JAGTAP, Ashutosh; ROY, Mita; HARIHARAN Sivaramakrishnan; “An improved process for preparation of perindopril intermediate”, PCT Publication No.: WO2014/057404, Published on April 17, 2014

SINORE, Sandip, SHAH, Chirag, JAGTAP, Ashutosh, ROY, Mita, HARIHARAN Sivaramakrishnan; “An improved process for the preparation of cinacalcet hydrochloride”, Indian Publication no.: 3068/MUM/2012A, Published on May 02, 2014

LADKAT Prashant; WAGH, Ganesh; JAGTAP, Ashutosh; ROY, Mita; HARIHARAN Sivaramakrishnan; CHOUKEKAR, Milind, “An improved process for the preparation of aprepitant”, PCT Publication No.: WO2013124823A1, Published on August 29, 2013

1WAGH, Ganesh; KUMBHAR, Ajay; JAGTAP, Ashutosh; ROY, Mita; HARIHARAN Sivaramakrishnan; “Benzylation process in aqueous medium for controlling donepezil benzyl chloride impurity in manufacture of donepezil hydrochloride”, Indian Patent Application No.: 1877/MUM/2013, Filed on May 28, 2013

KADAM, Shashikant; ARADDY, Rajshekar; KONDRAGUNTA, Venkateswara Rao; HULAVALE, Yogesh; SOMISETTI, Narender Rao; CHENNAMSETTY, Suneel Manohar Babu; HARIHARAN Sivaramakrishnan; “An improved process for minimising the formation of dehalogenated byproducts”, Indian Provisional Patent Application No: 3596/MUM/2013, Filed on November 18, 2013

LADKAT, Prashant; JAGTAP, Ashutosh; ROY, Mita; HARIHARAN Sivaramakrishnan; “An improved process for producing a solid form of dibenzyl fosaprepitant”, Indian Patent Application No.: 1180/MUM/2013, Filed on March 28, 2013

MARIADAS, Arulselvan; KUPPUSWAMY, Nagarajan; HARIHARAN, Sivaramakrishnan; An improved process for the preparation of Gabalactam; WO2004046108; IPC:C07D209/54

SUBRAYASHASTRY, Aravinda; HARIHARAN, Sivaramakrishnan; BALAKRISHNAN, Suresh Babu; KUPPANA, Ananda; IYER VENKATACHALAM Shankar, PREMA GOURIAMMA Vasudev, KUPPUSWAMY, Nagarajan, KARUPPIAH MURUGA POOPATI Raja, NARAYANASWAMY, Shamala; PADMANABHAN Balaram; KRISHNAMURTHI, Gopalakrishnan; 4-T-Butylgabapentin and its synthesis; IPC:C07C227/18C07C233/08C07C229/28A61H23/00C07C235/74A61H23/04A61H1/00

MARIADAS, Arulselvan; KUPPUSWAMY, Nagarajan; HARIHARAN, Sivaramakrishnan; Process for the preparation of Amino Methyl Cyclo Alkane Acetic Acids; WO2004046085; IPC:C07C227/38C07C227/18C07C227/42C07C229/28