The molecular complexity argument
This is a post that introduces the idea of molecular complexity and FBLD. In 2001, Hann and colleagues GSK developed the theory of molecular complexity, an idea that largely revolves around the principle that simpler molecules can be accommodated in a variety of protein sites compared to their more complex counterparts. The fact that molecular simplicity is inherently linked to molecular size meant that the tenet of molecular complexity could provide a likely explanation for successes within....